Pyridine → HCID 123168409, compound

Participants

Reaction Steps

Compound 16d (600 mg crude) was dissolved in acetonitrile (15 mL), acetic anhydride (1 mL) and pyridine (1 mL) were added to the reaction mixture and stirred at rt for 16 h. The reaction mixture was evaporated to dryness. To the crude was added THF/water (1:1, 50 mL) followed by lithium hydroxide 1.5 g and the reaction was stirred at rt for 16 h. The reaction mixture was concentrated under vacuum to dryness. The resulting residue was adjusted to pH 5 with dilute HCl and the resulting suspension was stirred for some time following which the solid formed was filtered, dried under vacuum and purified by reverse phase HPLC.

Provenance & Evidence