Piperidine → HCID 72195769, compound

Participants

Reaction Steps

A Biotage Process Vial (5-20 mL) was charged with 4-7 mol % of (2,2′-Bis(diphenylphosphino)-1,1′-binaphthyl) BINAP, 1-2 mol % of Pd2(dba)3, compound 15 or 23 (1 equivalent), morpholine or piperidine (2-5 equivalents), and potassium tertbutoxide (2-4 equivalents). The vial was charged with DMF (5-10 mL) and irradiated at 100-130° C. for 1 h, using the microwave reactor Smith Synthesizer. After irradiation, the sample was cooled and diluted with water and extracted with ethyl acetate (3×50 mL). The organic layer was washed with water, brine and dried over Na2SO4 and the solvent evaporated to dryness to afford crude 28 or 29. Purified material was obtained by preparative HPLC.

Provenance & Evidence