Lithium hydroxide, monohydrate → HCID 72195898, compound

Participants

Reaction Steps

Compound 26 (0.23 mmol,) was dissolved in THF/H2O (1:1, 20 mL) mixture. LiOH.H2O (0.35 mmol,) was added to the reaction mixture and stirred at room temperature for 3 h. The reaction mixture was concentrated under vacuum to dryness. The resulting residue was adjusted to pH 5 with dilute HCl and extracted with ethyl acetate (3×10 mL), washed with water and brine. The organic layer was dried over Na2SO4, filtered, and the solvent was removed in vacuo. The resulting solid was purified using reverse phase column chromatography to afford pure 27 as a white solid.

Provenance & Evidence