反应详情

1-Benzyl-3-(3,5-dichlorophenyl)-3-(trifluoromethyl)-2,3-dihydro-1H-pyrrole (100 mg, 90% purity, 242 μmol) was dissolved in tetrahydrofurane (2 mL) and sodium borohydride (26.0 mg, 677 μmol) was added at room temperature. After 30 minutes at room temperature the reaction mixture was acidified with hydrochloric acid (3.6%) and extracted twice with dichloromethane. The combined organic phases were washed with water, dried over sodium sulfate, filtered and the solvents evaporated. This procedure yielded 1-benzyl-3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidine (80.0 mg, 79% purity, 70% yield).

1. extractionextracted twice with dichloromethane
2. washThe combined organic phases were washed with water
3. dry with materialdried over sodium sulfate
4. filtrationfiltered
5. customthe solvents evaporated