p-Bromoacetophenone → HCID 25023178, compound

Participants

Reaction Steps

To a solution of 1-(4-bromophenyl)ethanone (2.0 g, 10 mmol) and (S)-2-methylpropane-2-sulfinamide (1.2 g, 10 mmol) in THF (20 mL) was added Ti(OiPr)4 (5 mL). The reaction mixture was refluxed overnight. The mixture was quenched with sat. NH4Cl solution and diluted with EtOAc. The mixture was filtered through a pad of Celite and washed with EtOAc. The layers were separated and the organic layer was washed with brine, dried and concentrated to give the titled compound.

Provenance & Evidence