HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Dimethylbutylamine → HCID 118072726, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Dimethylbutylamine | HCID 7908 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 118072725 | HCID 118072725 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 118072726 | HCID 118072726 | — |
Reaction Steps
The mixture of 1-((2′-(tert-butoxycarbonyl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-5-carboxylic acid (45 mg, 0.105 mmol), 4-methylpentan-2-amine (12.7 mg, 0.126 mmol), HATU (78 mg, 0.315 mmol) and DIPEA (27 mg, 0.315 mmol) in 10 mL of DCM was stirred at RTovernight. Then the solvent was removed under the reduced pressure to give the residue which was purified with prep-TLC (hexane/EtOAc=1/1, silica gel) to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09309227B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-7e21ebbb6acd44aaa4133b95a1c537f7 |
| Source note | uspto-grants-2016_04 |