HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isobutyraldehyde → 3-(4-Chloro-phenyl)-3-({4-[2-(2,5-dioxo-pyrrolidin-1-yl)-ethoxy]-3-methoxy-benzyl}-isobutyl-amino)-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isobutyraldehyde | HCID 6561 | — |
| Reactant | Ethyl β-amino-4-chlorobenzenepropanoate | HCID 2847357 | — |
| Reactant | 4-[2-(2,5-Dioxo-pyrrolidin-1-yl)-ethoxy]-3-methoxy-benzaldehyde | HCID 89610696 | — |
| Product | 3-(4-Chloro-phenyl)-3-({4-[2-(2,5-dioxo-pyrrolidin-1-yl)-ethoxy]-3-methoxy-benzyl}-isobutyl-amino)-propionic acid | HCID 72549347 | — |
Reaction Steps
Following procedures outlined in Example 1 step 1 is accomplished with 3-Amino-3-(4-chloro-phenyl)-propionic acid ethyl ester (5.2) and Intermediate 4.1 then using 2-methyl-propionaldehyde (3.1) in step 2 after acidic hydrolysis and purification the title compound is isolated as a white foam. Molecular Formula=C27H33ClN2O6; (M+H)+=517; Rt=2.53 min (A), purity 98.8%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09447038B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-5db5c89920874f00b6cf57e684b577cb |
| Source note | uspto-grants-2016_09 |