HCID 118106777, compound → HCID 131735219, compound

Participants

Reaction Steps

3.19 g (5.87 mmol) of tert-butyl 3-[3-({N-[(benzyloxy)carbonyl]-4,4,4-trifluorovalyl}amino)-4-chlorophenyl]propanoate (Example 34A, racemic diastereomer mixture) were dissolved in 50 ml of ethyl acetate. The solution was inertized with argon, and 125 mg of palladium on carbon (5%) were added. The reaction mixture was stirred vigorously at standard pressure under an atmosphere of hydrogen for 3 h. After filtration through kieselguhr, the filtrate was concentrated under reduced pressure. The residue was purified by chromatography on silica gel (mobile phase cyclohexane/ethyl acetate 50:1→3:1) and the diastereomers were separated:

Provenance & Evidence