Ammonium Chloride → HCID 90410556, compound

Participants

Reaction Steps

A solution of 4-methyl-N-(4-((6-nitropyridin-3-yl)oxy)pyridin-2-yl)piperazine-1-carboxamide (0.400 g, 1.116 mmol) in MeOH (20 mL) was treated with NH4Cl (2.00 g, 37.4 mmol) and zinc powder (1.00 g, 15.29 mmol) and stirred at RT overnight. The solids were removed via filtration, washed with DCM and the filtrate concentrated to dryness. The residue was treated with DCM and a few drops of MeOH, the solids again removed via filtration and the filtrate concentrated to dryness to afford N-(4-((6-aminopyridin-3-yl)oxy)pyridin-2-yl)-4-methylpiperazine-1-carboxamide (346 mg, 94%). MS (ESI) m/z: 329.2 (M+H+).

Provenance & Evidence