HCID 90409812, compound → HCID 90410556, compound

Participants

Reaction Steps

A suspension of 4-methyl-N-(4-((6-nitropyridin-3-yl)oxy)pyridin-2-yl)piperazine-1-carboxamide, DN-01540-085-1 (6.40 g, 17.86 mmol) and Raney Nickel (1.00 g, 17.26 mmol) in MeOH (100 mL) was hydrogenated (40 psi) in a Parr shaker flask at RT for 2 h. The catalyst from the reaction mixture was removed by filtration and washed with MeOH. The filtrate was evaporated to provide N-(4-((6-aminopyridin-3-yl)oxy)pyridin-2-yl)-4-methylpiperazine-1-carboxamide (5.80 g, 99%) as light brownish solid. MS (ESI) m/z: 329.2 (M+H+).

Provenance & Evidence