Hydrazine hydrate (1:1) → HCID 90411100, compound

Participants

Reaction Steps

A solution of N-(4-((6-nitropyridin-3-yl)oxy)pyridin-2-yl)isobutyramide (1.08 g, 3.57 mmol) in MeOH (30 mL) was treated with hydrazine hydrate (1.00 g, 19.98 mmol) followed by Raney Nickel (0.300 g, 5.11 mmol) and stirred at RT for 3 h. The solids were removed via filtration through diatomaceous earth, washed with DCM and MeOH and the filtrate concentrated to dryness to afford N-(4-((6-aminopyridin-3-yl)oxy)pyridin-2-yl)isobutyramide (900 mg, 93%) as an off-white solid. MS (ESI) m/z: 273.2 (M+H+).

Provenance & Evidence