Ammonium Chloride → HCID 90409862, compound

Participants

Reaction Steps

A solution of 4-methyl-N-(4-((2-methyl-6-nitropyridin-3-yl)oxy)pyridin-2-yl)piperazine-1-carboxamide (0.400 g, 1.074 mmol) in MeOH (20 mL) was treated with NH4Cl (2.00 g, 37.4 mmol) followed by zinc powder (1.00 g, 15.29 mmol) and the mixture stirred at RT overnight. The solids were removed via filtration, washed with DCM and the filtrate concentrated to dryness. The residue was treated with DCM and a few drops of MeOH, the solids again removed via filtration and the filtrate concentrated to dryness to afford N-(4-((6-amino-2-methylpyridin-3-yl)oxy)pyridin-2-yl)-4-methylpiperazine-1-carboxamide (290 mg, 79%). MS (ESI) m/z: 343.2 (M+H+).

Provenance & Evidence