反应详情

A stirred solution of 2-methylcyclohexanone (5 g, 44.64 mmol) and (R)-1-phenylethanamine (5.4 g, 44.64 mmol) in toluene (50 mL) was maintained at 140-145° C. for 24 h. The solvent was removed under reduced pressure to afford 8 g (84%) of a diastereomeric mixture of (1R,E)-N-(2-methylcyclohexylidene)-1-phenylethanamine (I-8a) as a pale yellow oil.

1. customThe solvent was removed under reduced pressure