反应详情

A suspension of (1R,E)-N-(2-methylcyclohexylidene)-1-phenylethanamine (I-8a: 25 g, 116.27 mmol) and Raney-Ni (3.75 g) in ethanol (250 mL) was maintained under hydrogen atmosphere in a Parr hydrogenator using 5 bar pressure for 2 days. The reaction mixture was filtered and filtrate evaporated under reduced pressure. The crude compound was treated with ethereal HCl, and the precipitated salt was filtered, washed with cold ether and dried to afford 20 g (80%) of 2-methyl-N—((R)-1-phenylethyl)-cyclohexanamine (I-8b) as a white solid.

1. temperaturewas maintained under hydrogen atmosphere in a Parr hydrogenator
2. customfor 2 days
3. filtrationThe reaction mixture was filtered
4. customfiltrate evaporated under reduced pressure
5. additionThe crude compound was treated with ethereal HCl
6. filtrationthe precipitated salt was filtered
7. washwashed with cold ether
8. customdried