反应详情

温度

0 °C

Under argon, 300 mg (0.814 mmol) of the compound from example 6A were initially charged in pyridine (10 ml), the mixture was cooled to 0° C. and 78 μl (0.814 mmol) of ethyl chloroformate were then added dropwise. The reaction mixture was stirred at 0° C. for 1 h and then concentrated. The residue was separated by means of preparative RP-HPLC (acetonitrile:water (+0.1% formic acid)−gradient) and the product fractions were concentrated. This gave 77 mg (21% of theory) of the title compound.

1. concentrationconcentrated
2. customThe residue was separated by means of preparative RP-HPLC (acetonitrile:water (+0.1% formic acid)−gradient)
3. concentrationthe product fractions were concentrated