反应详情

To a solution of 6-(benzyloxy)-N-cyclohexyl-4-methyl-1H-indole-2-carboxamide (I-9A-a: 1.5 g, 4.14 mmol) in ethanol (30 mL) was added 10% Pd—C (300 mg) and the mixture placed in a Parr hydrogenator (50 psi) at room temperature for 6 h. The reaction mixture was filtered through celite pad and washed with ethanol (30 mL), concentrated under reduced pressure to afford 1.2 g (90%) of N-cyclohexyl-6-hydroxy-4-methyl-1H-indole-2-carboxamide (I-9A-b) as an off-white solid.

1. filtrationThe reaction mixture was filtered through celite pad
2. washwashed with ethanol (30 mL)
3. concentrationconcentrated under reduced pressure