Tetrabutylammonium Fluoride → HCID 87593948, compound

Participants

Reaction Steps

200 mg (0.38 mmol) Compound 24 was dissolved in 10 ml THF, to which 720 mg TBAF (tetrabutylammonium fluoride) (6 mmol) was added. The mixture was stirred at room temperature for 1 hour. TLC showed the dot of starting material disappeared. THF was evaporated off under reduced pressure. 40 ml EtOAc was added to the residue. The mixture was successively washed with 20 ml water and saturated NaCl solution, dried with anhydrous Na2SO4, and filtered. The filtrate was evaporated to dryness under reduced pressure, to afford 52 mg (47%) of title compound as light yellow solid.

Provenance & Evidence