Methyl Isocyanate → 1-[2-(2,6-Dichlorophenyl)-2H-pyrazolo[4,3-c]pyridine-4-yl]-3-methylurea

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Reaction Steps

Following the procedure described for [2-(2,6-dichlorophenyl)-2H-pyrazolo[4,3-c]pyridine-4-yl]carbamic acid methyl ester, 2-(2,6-dichlorophenyl)-2H-pyrazolo[4,3-c]pyridine-4-ylamine and methyl isocyanate were reacted to afford the title compound as a white solid (78% yield). 1H NMR (400 MHz, DMSO-d6): δ 10.06 (br s, 1H), 9.75-9.70 (m, 1H), 9.04 (d, J=0.9 Hz, 1H), 7.85 (d, J=6.5 Hz, 1H), 7.83-7.76 (m, 2H), 7.70 (dd, J=9.0, 7.3 Hz, 1H), 7.17 (dd, J=6.5, 0.9 Hz, 1H), 2.84 (d, J=4.6 Hz, 3H). LCMS (Method B): RT=2.69 min, m/z: 336 [M+H+].

Provenance & Evidence