(6-Aminopyrimidin-4-yl)methanol → 3,5-Dichloro-4-[4-(6-hydroxymethyl-pyrimidin-4-ylamino)-pyrazolo[4,3-c]pyridin-2-yl]-benzonitrile

Participants

Reaction Steps

Following the procedure described for 3,5-dichloro-4-[4-(2,6-dimethylpyrimidin-4-ylamino)pyrazolo[4,3-c]pyridin-2-yl]benzonitrile, (6-amino-pyrimidin-4-yl)-methanol and 3,5-dichloro-4-(4-chloropyrazolo[4,3-c]pyridin-2-yl)benzonitrile were reacted to afford the title compound as a pale yellow solid (70 mg, 37% yield). 1H NMR (400 MHz, DMSO-d6): δ 10.76 (s, 1H), 9.22 (s, 1H), 8.70 (s, 2H), 8.49 (s, 2H), 8.00 (d, J=6.4 Hz, 1H), 7.25-7.22 (m, 1H), 5.61 (t, J=5.7 Hz, 1H), 4.53 (d, J=5.8 Hz, 2H). LCMS (Method D): RT=2.05 min, m/z: 412 [M+H+].

Provenance & Evidence