Hydrochloric Acid → HCID 69671804, compound

Participants

Reaction Steps

A mixture of 4-[4-(6-aminopyrimidin-4-ylamino)-7-fluoropyrazolo[4,3-c]pyridin-2-yl]-3,5-dichlorobenzonitrile (77 mg, 0.19 mmol) and HCl (4 N in dioxane, 5.0 mL, 20 mmol) was stirred at room temperature for 2 hours. The reaction mixture was concentrated under reduced pressure and the residue was dried to afford the title compound as an off-white solid (81 mg, 96% yield). 1H NMR (400 MHz, DMSO-d6): δ 9.45 (d, J=2.3 Hz, 1H), 8.57 (s, 1H), 8.50 (s, 2H), 8.03 (d, J=3.3 Hz, 1H), 7.25 (br s, 1H). LCMS (Method B): RT=3.16 min, m/z: 415 [M+H+].

Provenance & Evidence