3,5-Dichloro-4-(7-chloropyrazolo[4,3-c]pyridin-2-yl)benzonitrile → 4-(7-Bromo-pyrazolo[4,3-c]pyridin-2-yl)-3,5-dichlorobenzonitrile

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Reaction Steps

Following the procedure described for 3,5-dichloro-4-(7-chloropyrazolo[4,3-c]pyridin-2-yl)benzonitrile, 4-{[1-(4-azido-5-bromo-pyridin-3-yl)-meth-(E)-ylidene]-amino}-3,5-dichlorobenzonitrile was heated under reflux in toluene to afford the title compound as a beige solid (3.57 g, 70% yield). 1H NMR (300 MHz, methanol-d4): δ 9.26 (s, 1H), 9.06 (s, 1H), 8.46 (s, 1H), 8.20 (s, 2H).

Provenance & Evidence