HCID 69671428, compound → HCID 89809806, compound

Participants

Reaction Steps

A solution of {6-[7-bromo-2-(2,6-dichlorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-pyrimidin-4-yl}-carbamic acid tert-butyl ester (95 mg, 0.18 mmol) in DCM (2 mL) and TFA (1 mL) was stirred at room temperature for 3 hours. The solvent was removed and the residue partitioned between DCM and NaHCO3 (sat. aq.). The organic layer was washed with brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel flash chromatography (70-90% ethyl acetate in cyclohexane), to afford the title compound as a white solid (23 mg, 29% yield). 1H NMR (400 MHz, DMSO-d6): δ 10.22 (s, 1H), 9.29 (s, 1H), 8.15 (d, J=0.9 Hz, 1H), 8.04 (s, 1H), 7.84 (d, J=1.2 Hz, 1H), 7.82 (s, 1H), 7.73 (dd, J=7.1 and 9.0 Hz, 1H), 7.59 (d, J=1.2 Hz, 1H), 6.74 (br s, 2H). LCMS (Method B): RT=3.25 min, m/z: 450 [M+H+].

Provenance & Evidence