Potassium methoxide → 2-(2,6-dichlorophenyl)-7-methoxy-2H-pyrazolo[4,3-c]pyridine 5-oxide

Participants

Reaction Steps

A suspension of 2-(2,6-dichlorophenyl)-7-fluoro-2H-pyrazolo[4,3-c]pyridine-5-oxide (1.5 g, 5 mmol) and potassium methoxide (525 mg, 7.5 mmol) in methanol (10 mL) was sealed in a microwave vial, purged with nitrogen and irradiated at 150° C. for 30 minutes in the microwave. The reaction mixture was cooled and partitioned between ethyl acetate and water. The organic layer was washed with brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was triturated with ether to afford the title compound as a beige solid (1.32 g, 85% yield). LCMS (Method D): RT=2.31 min, m/z: 310 [M+H+].

Provenance & Evidence