反应详情

A suspension of [1-(4-azido-5-fluoropyridin-3-yl)-meth-(E)-ylidene]-(2,6-dichloro-4-fluorophenyl)-amine (14.7 mmol) in toluene (40 mL) was heated under reflux for 16 hours then allowed to cool to room temperature. The reaction mixture was concentrated under reduced pressure. The residue was purified by silica gel flash chromatography (0-50% ethyl acetate in cyclohexane) to afford the title compound as an off-white solid (3.38 g, 77% yield). LCMS (Method D): RT=2.84 min, m/z: 300 [M+H+].

1. temperaturewas heated
2. temperatureunder reflux for 16 hours
3. concentrationThe reaction mixture was concentrated under reduced pressure
4. customThe residue was purified by silica gel flash chromatography (0-50% ethyl acetate in cyclohexane)