6-Methylpyrimidin-4-amine → [2-(2,6-Dichloro-4-fluorophenyl)-7-fluoro-2H-pyrazolo[4,3-c]pyridin-4-yl]-(6-methylpyrimidin-4-yl)-amine

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Reaction Steps

Following the procedure described for 3,5-dichloro-4-[7-chloro-4-(6-methylpyrimidin-4-ylamino)pyrazolo[4,3-c]pyridin-2-yl]benzonitrile, 4-bromo-2-(2,6-dichloro-4-fluorophenyl)-7-fluoro-2H-pyrazolo[4,3-c]pyridine and 6-methylpyrimidin-4-ylamine were reacted to afford the title compound as a white solid (38 mg, 36% yield). 1H NMR (400 MHz, DMSO-d6): δ 10.72 (s, 1H), 9.26 (d, J=2.6 Hz, 1H), 8.69 (d, J=1.2 Hz, 1H), 8.36 (s, 1H), 7.98 (d, J=3.5 Hz, 1H), 7.96 (s, 1H), 7.94 (s, 1H), 2.44 (s, 3H). LCMS (Method B): RT=3.44 min, m/z: 407 [M+H+].

Provenance & Evidence