反应详情

温度

107 °C

Following the procedure described for 2-(2,6-dichloro-4-nitrophenyl)-7-fluoro-2H-pyrazolo[4,3-c]pyridine, 2-{[1-(4-azido-5-fluoropyridin-3-yl)-meth-(E)-ylidene]-amino}-3-chloro-5-nitrobenzonitrile was heated at 107° C. for 3.5 hours. After purification by silica gel chromatography (0-5% methanol in DCM), the product was triturated 5 times with diethyl ether/cyclohexane (1:1) to afford the title compound as a yellow solid (3.31 g, 58% yield). LCMS (Method C): RT=2.89 min, m/z: 318 [M+H+].

1. customAfter purification by silica gel chromatography (0-5% methanol in DCM)
2. customthe product was triturated 5 times with diethyl ether/cyclohexane (1:1)