4-Bromo-2-(2,6-dichloro-4-nitrophenyl)-7-fluoro-2H-pyrazolo[4,3-c]pyridine → 2-(4-Bromo-7-fluoropyrazolo[4,3-c]pyridin-2-yl)-3-chloro-5-nitrobenzonitrile

Participants

Reaction Conditions

Reaction Steps

Following the procedure described for 4-bromo-2-(2,6-dichloro-4-nitrophenyl)-7-fluoro-2H-pyrazolo[4,3-c]pyridine, 3-chloro-2-(4-chloro-7-fluoropyrazolo[4,3-c]pyridin-2-yl)-5-nitrobenzonitrile was heated at 100° C. overnight to afford the title compound as a pale yellow solid (1.38 g, 83% yield). LCMS (Method C): RT=3.62 min, m/z: 396 [M+H+].

Provenance & Evidence