反应详情

温度

70 °C

Following the procedure described for [2-(4-amino-2,6-dichlorophenyl)-7-fluoro-2H-pyrazolo[4,3-c]pyridin-4-yl]-(6-methylpyrimidin-4-yl)-amine, 3-chloro-2-[7-fluoro-4-(6-methylpyrimidin-4-ylamino)-pyrazolo[4,3-c]pyridin-2-yl]-5-nitrobenzonitrile was heated at 70° C. for 7 h to afford the title compound as a pale yellow solid (27 mg, 30% yield). 1H NMR (400 MHz, DMSO-d6): δ 10.68 (s, 1H), 9.26 (d, J=2.6 Hz, 1H), 8.68 (d, J=1.2 Hz, 1H), 8.37 (s, 1H), 7.97 (d, J=3.5 Hz, 1H), 7.13-7.08 (m, 2H), 6.48 (s, 2H), 2.43 (s, 3H). LCMS (Method B): RT=2.88 min, m/z: 395 [M+H+].