Bromotrimethylsilane → HCID 86697078, compound

Participants

Reaction Conditions

Reaction Steps

2-(4-Chloro-7-fluoropyrazolo[4,3-c]pyridin-2-yl)-3-fluorobenzonitrile (520 mg, 1.79 mmol) was suspended in propionitrile (35 mL), under an atmosphere of nitrogen and bromotrimethylsilane (0.646 mL, 6.76 mmol) was added. The reaction mixture was heated at 80° C. for 4.5 hours. The resultant mixture was cooled to room temperature and concentrated under reduced pressure. The residue was partitioned between ethyl acetate and saturated aqueous sodium bicarbonate solution. The layers were separated and the organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford the title compound as a solid (600 mg, 100% yield). This was used in the next step without purification. LCMS (Method F): RT=3.30 min, m/z: 335 [M+H+].

Provenance & Evidence