Hydrochloric Acid → HCID 69671569, compound

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Reaction Steps

A solution of 3-fluoro-2-[7-fluoro-4-(6-methylpyrimidin-4-ylamino)-pyrazolo[4,3-c]pyridin-2-yl]-benzonitrile (46 mg, 0.13 mmol) in 1.25 N HCl in propan-2-ol solution (2.5 mL) was heated at 50° C. for 2 hours. The resultant mixture was concentrated under reduced pressure and the residue was dried at 50° C. under high vacuum overnight to afford the title compound as an off-white solid (60 mg, 100% yield). 1H NMR (400 MHz, DMSO-d6): δ 9.64 (br s, 1H), 9.06 (s, 1H), 8.39 (br s, 1H), 8.15 (d, J=3.5 Hz, 1H), 8.11-8.02 (m, 2H), 7.97-7.90 (m, 1H), 2.61 (s, 3H). LCMS (Method B): RT=2.92 min, m/z: 364 [M+H+].

Provenance & Evidence