HCID 178509437, compound → HCID 69671939, compound

Participants

Reaction Steps

A solution of 2-{[1-(4-azido-5-fluoropyridin-3-yl)meth-(E)-ylidene]amino}-5-bromo-3-chlorobenzonitrile (˜22.6 mmol) in toluene (100 mL) was heated under reflux for 5 hours. The resultant mixture was cooled to room temperature and concentrated under reduced pressure. The residue was triturated with diethyl ether and the solid obtained was collected by filtration and dried to afford the title compound as an off-white solid (4.61 g, 58% yield over two steps). 1H NMR (400 MHz, DMSO-d6): δ 9.37 (d, J=2.7 Hz, 1H), 9.27 (d, J=2.6 Hz, 1H), 8.61-8.58 (m, 2H), 8.34 (d, J=3.8 Hz, 1H).

Provenance & Evidence