Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester → 3-Methyl-hept-2-enedioic acid dimethyl ester, E

Participants

Reaction Steps

A solution of methyl 5-oxopentanoate (1.9 g, 14.6 mmol) and (carboethoxymethylene) triphenylphosphorane (5.0 g, 14.9 mmol) in toluene (50 mL) was refluxed for 8 hours. Solvent was removed under vacuo and the crude was purified by flash chromatography on silica gel (eluant: AcOEt/hexane 2/8) to give 1.32 g (48% yield) as colorless oil of the title compound.

Provenance & Evidence