HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 626870Generated: November 1, 2026
N,N,N',N',N'',N''-Hexamethylmethanetriamine → Methyl (6E)-6-[(dimethylamino)methylidene]-1-methyl-7-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylate
https://huagongshe.com/reaction/626870
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N,N,N',N',N'',N''-Hexamethylmethanetriamine | HCID 79831 | — |
| Reactant | Methyl 1-methyl-7-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylate | HCID 68276330 | — |
| Product | Methyl (6E)-6-[(dimethylamino)methylidene]-1-methyl-7-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylate | HCID 68356011 | — |
Reaction Steps
Methyl 1-methyl-7-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylate (288 mg, 1.39 mmol) was treated with tris(dimethylamino)methane (2.4 mL, 13.9 mmol) and the reaction mixture was stirred at 90° C. for 10 h. Volatiles were removed under reduced pressure and the residue used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09309253B2 |
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| Source dataset | uspto-grants-2016_04 |
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| ORD ID | ord-e9fb28d5f15548ff98ae9ac24c8c7b16 |
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| Source note | uspto-grants-2016_04 |
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