Hydrochloric Acid → HCID 72549752, compound

Participants

Reaction Steps

In a similar manner, tert-butyl (2R,5R)-2-[4-methyl-6-[4-(trifluoromethyl)phenyl]pyrimidin-2-yl]-6-oxo-1,7-diazaspiro[4.4]nonane-1-carboxylate (37 mg) was converted first to the free base (2R,5R)-2-[4-methyl-6-[4-(trifluoromethyl)phenyl]pyrimidin-2-yl]-1,7-diazaspiro[4.4]-nonan-6-one (27 mg); m/z 377 (M+H+); Optical Rotation α[D/20)]=+32.1 (c=0.56, CHCl3). This material was subsequently treated with HCl in ether to form (2R,5R)-2-[4-methyl-6-[4-(trifluoromethyl)-phenyl]pyrimidin-2-yl]-1,7-diazaspiro[4.4]nonan-6-one hydrochloride (E42) (32 mg); m/z 377 (M+H+).

Provenance & Evidence