(2-Chloropyrimidin-5-yl)boronic acid → HCID 119087136, compound

HRID 626968Notes

Reaction equation

HRID 626968 reaction equation
Cl.[NH:2]1[CH2:7][CH2:6][CH:5]([S:8]([NH2:11])(=[O:10])=[O:9])[CH2:4][CH2:3]1.Cl[C:13]1[N:18]=[CH:17][C:16]([B:19]([OH:21])[OH:20])=[CH:15][N:14]=1>>[S:8]([CH:5]1[CH2:6][CH2:7][N:2]([C:13]2[N:18]=[CH:17][C:16]([B:19]([OH:21])[OH:20])=[CH:15][N:14]=2)[CH2:3][CH2:4]1)(=[O:10])(=[O:9])[NH2:11]

Participants

3

Reactant 2

HCID 21747362(2-Chloropyrimidin-5-yl)boronic acidHCID 50988742piperidine-4-sulfonamide:hydrochloride

Product 1

HCID 119087136HCID 119087136, compound

Procedure

Prepared from piperidine-4-sulfonamide hydrochloride (1.27 g, 6.315 mmol) and (2-chloropyrimidin-5-yl)boronic acid (1 g, 6.32 mmol) in accordance with General Method C to give the title compound as an off-white semi-solid. HPLC-MS: m/z (M−H)+ 285.1, RT 0.14 minutes.

Sources & evidence

ORD record
ord-734ed9ec769d46e39ffae37e5f386410
Source dataset
uspto-grants-2016_04
Patent number
US09309243B2

Reaction notes

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