(2-Chloropyrimidin-5-yl)boronic acid → HCID 178514838, compound

HRID 626970Notes

Reaction equation

HRID 626970 reaction equation
Cl.[NH:2]1[CH2:7][CH2:6][CH:5]([C:8]2[O:12][C:11]([OH:13])=[N:10][N:9]=2)[CH2:4][CH2:3]1.Cl[C:15]1[N:20]=[CH:19][C:18]([B:21]([OH:23])[OH:22])=[CH:17][N:16]=1>>[OH:13][C:11]1[O:12][C:8]([CH:5]2[CH2:4][CH2:3][N:2]([C:15]3[N:20]=[CH:19][C:18]([B:21]([OH:23])[OH:22])=[CH:17][N:16]=3)[CH2:7][CH2:6]2)=[N:9][N:10]=1

Participants

3

Reactant 2

HCID 21747362(2-Chloropyrimidin-5-yl)boronic acidHCID 178479662HCID 178479662, compound

Product 1

HCID 178514838HCID 178514838, compound

Procedure

Prepared from 5-(piperidin-4-yl)-1,3,4-oxadiazol-2-ol hydrochloride (1.30 g, 6.32 mmol) and (2-chloropyrimidin-5-yl)boronic acid (1 g, 6.32 mmol) in accordance with General Method C to give the title compound as an off-white semi-solid. HPLC-MS: m/z (M−H)+ 290.2, RT 0.17 minutes.

Sources & evidence

ORD record
ord-fbbd7df889394c0ca34d20784dedfe32
Source dataset
uspto-grants-2016_04
Patent number
US09309243B2

Reaction notes

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