HCID 118235427, compound → HCID 118235457, compound

Participants

Reaction Steps

A solution of Example 163 (˜0.05M, 545 mg, 1.01 mmol) in ethanol was hydrogenated using an H-Cube® (ThalesNano) at a flow rate of 0.5 mL/minute, in full H2 mode (1 bar) at 50° C. Removal of the ethanol under vacuum gave the title compound (545 mg, 89%) as a pale brown foam consisting of a pair diastereosiomers in a 3:1 ratio. δH (300 MHz, CD3OD) 8.76 (s, 2H), 8.24 (d, J 7.4 Hz, 1H), 7.25 (m, 2H), 7.07 (m, 3H), 6.81 (t, J 74.1 Hz, 1H), 4.32 (s, 2H), 4.09 (2H, qd, J 7.3, 1.2 Hz), 2.97 (m, 1H), 2.64 (m, 1H), 2.33 (m, 1H), 1.83 (m, 8H), 1.21 (t, J 7.1 Hz, 3H). LC-MS (pH 3): MH+ m/z 539.8, RT 2.46 minutes; 539.8, RT 2.51 minutes. LC-MS (pH 10): MH+ m/z 539.8, RT 2.47 minutes; 539.8, RT 2.51 minutes.

Provenance & Evidence