Sodium Hydroxide → HCID 118235787, compound

Participants

Reaction Conditions

Reaction Steps

Sodium hydroxide (7 mg, 0.175 mmol) was added to a solution of Example 174 (0.1 g, 0.176 mmol) in THF-MeOH-water, 1:1:1 (4 mL). The mixture was stirred at 70° C. for 2 h. The mixture was concentrated and diluted with water, then washed with EtOAc. The aqueous layer was freeze-dried. The resulting material (95 mg) was purified by HPLC to give the title compound (30 mg, 30%) as a white lyophilised solid. δH (400 MHz, DMSO-d6) 8.48 (m, 2H), 8.34 (d, J 7.5 Hz, 1H), 7.46 (m, 1H), 7.30 (m, 1H), 7.26 (t, J 72 Hz, 1H), 7.19 (m, 1H), 7.14 (td, J 7.5, 1.1 Hz, 1H), 7.02 (m, 1H), 4.39 (m, 2H), 4.34 (s, 2H), 3.43 (s, 2H), 3.23 (m, 2H), 2.28 (s, 3H), 1.98 (m, 2H), 1.40 (m, 2H). LCMS (pH 10): MH+ 542, RT 1.44 minutes.

Provenance & Evidence