Sodium Hydroxide → HCID 118235510, compound

Participants

Reaction Conditions

Reaction Steps

Sodium hydroxide (7.5 mg, 0.188 mmol) was added to a solution of Example 177 (0.104 g, 0.188 mmol) in THF-MeOH-water, 1:1:1 (4 mL). The mixture was stirred at 70° C. for 3 h. The reaction mixture was concentrated, diluted with water and washed with diethyl ether, then the aqueous layer was freeze-dried, to give the title compound (100 mg, 100%) as a white lyophilised solid. δH (400 MHz, DMSO-d6) 8.21 (d, J 1.3 Hz, 2H), 8.12 (d, J 7.5 Hz, 1H), 7.22 (m, 1H), 7.08 (m, 1H), 7.05 (t, J 72, 76 Hz, 1H), 6.97 (m, 1H), 6.92 (m, 1H), 6.81 (dd, J 7.5, 1.1 Hz, 1H), 4.12 (s, 2H), 4.04 (m, 1H), 3.96 (m, 1H), 3.43 (m, 1H), 3.07 (m, 1H), 2.07 (s, 3H), 1.76 (m, 1H), 1.50 (m, 1H), 1.15 (m, 1H), 0.72 (dd, J 8.7, 2.9 Hz, 1H), 0.00 (dd, J 5.4, 3.2 Hz, 1H). LCMS (pH 10): MH+ 524, RT 1.56 minutes.

Provenance & Evidence