Hydrochloric Acid → HCID 118235642, compound

Participants

Reaction Steps

To a solution of Example 257 (50 mg, 0.067 mmol) in 1,4-dioxane (5 mL) was added 4M HCl in 1,4-dioxane (5 mL, 20 mmol), and the reaction mixture was stirred for 3 h. The solvent was removed in vacuo, and the residue was freeze-dried, to afford the title compound (25 mg, 58%). δH (300 MHz, DMSO-d6) 9.23 (m, 2H), 8.68 (m, 1H), 8.63 (d, 2H, J 1.4 Hz), 7.86 (d, 1H, J 10.2 Hz), 7.29 (m, 4H), 7.19 (m, 1H), 7.12 (dd, 1H, J 7.8, 1.5 Hz), 7.08 (m, 2H), 6.77 (dd, 1H, J 8.0, 2.0 Hz), 5.25 (s, 2H), 4.56 (s, 2H), 4.43 (m, 2H), 4.02 (m, 6H), 3.19 (m, 4H). LCMS (ES+) 647 (M+H)+, RT 1.90 minutes.

Provenance & Evidence