Sodium Hydroxide → HCID 118235638, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of Example 297 (0.40 g, 0.71 mmol) in THF (4 mL) and methanol (4 mL) was added 1M aqueous sodium hydroxide solution (0.67 mL, 0.68 mmol), and the mixture was heated at 55° C. The mixture was stirred at room temperature overnight. The mixture was concentrated in vacuo to remove the organic solvents and the residue was treated with diethyl ether (50 mL). The ether was decanted and the aqueous layer was diluted with water, then freeze dried, to give the title compound (0.39 g, 97%) as an off-white solid. δH 1.07 (s, 3H), 1.22 (m, 2H), 2.02 (m, 2H), 2.28 (m, 2H), 2.35 (s, 3H), 4.29 (m, 4H), 6.99 (m, 1H), 7.14 (m, 2H), 7.24 (s, 1H), 7.30 (m, 2H), 7.49 (s, 1H), 7.75 (d, J 0.2 Hz, 1H), 8.30 (s, 1H), 8.36 (s, 2H). LCMS (pH 3): MH+ 540.0, RT 2.02 minutes. LCMS (pH 10): MH+ 540.0, RT 1.69 minutes.

Provenance & Evidence