反应详情

In a 50 mL round-bottomed flask, tert-butyl (S)-1-((S)-1-((S)-2-(2-fluoro-5-methylphenylcarbamoyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-1-yl)-3-methyl-1-oxobutan-2-ylamino)-1-oxopropan-2-yl(methyl)carbamate (49 mg, 88.2 μmol, Eq: 1.00) was combined with DCM (3 mL) to give a colorless solution. TFA (1.00 mL, 13.0 mmol, Eq: 147) was added. The reaction was stirred at rt for 1 h and then concentrated in vacuo. The residue taken up in DCM, washed with saturated aqueous NaHCO3, dried over Na2SO4 and concentrated in vacuo to give (S)-1-[(S)-3-Methyl-2-((S)-2-methylamino-propionylamino)-butyryl]-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid (2-fluoro-5-methyl-phenyl)-amide as a white foam (37 mg), m/z=456 (M+H).

1. customto give a colorless solution
2. concentrationconcentrated in vacuo
3. washwashed with saturated aqueous NaHCO3
4. dry with materialdried over Na2SO4
5. concentrationconcentrated in vacuo