Trifluoroacetic acid → HCID 73603782, compound

Participants

Reaction Steps

In a 50 mL round-bottomed flask, tert-butyl (S)-1-((S)-1-cyclohexyl-2-oxo-2-((S)-2-(phenylcarbamoyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-1-yl)ethylamino)-1-oxopropan-2-yl(ethyl)carbamate (33 mg, 57.1 μmol, Eq: 1.00) was combined with DCM (3 mL) to give a colorless solution. TFA (1 mL, 13.0 mmol, Eq: 227) was added. After 30 min, the crude reaction mixture was concentrated in vacuo. The residue was taken up in DCM, washed with saturated aqueous NaHCO3, dried over Na2SO4 and concentrated in vacuo to give (S)-1-[(S)-2-Cyclohexyl-2-((S)-2-ethylamino-propionylamino)-acetyl]-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid phenylamide as a white solid (23 mg), m/z=478 (M+H).

Provenance & Evidence