Potassium Hydroxide → HCID 90411382, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of the product from step (e) (3.45 g, 10.26 mmol) in EtOH (120 ml) was added 2M KOH (50 ml). The reaction mixture was heated to 50° C. for 6 hours and then allowed to cool to RT. The reaction mixture was then stirred at RT for an additional 12 hours. The MeOH was then evaporated in vacuo and the remaining aqueous mixture was diluted with additional water (50 ml). The aqueous mixture was washed with EtOAc (2×). The aqueous mixture was then acidified with 2M HCl to pH 2 and extracted with DCM (3×). The combined DCM extracts were dried (Na2SO4), decanted, and solvent evaporated in vacuo to give the sub-titled compound as a tan solid (3.0 g) that was used without further purification. MS: ESI (positive): 308 (M+H), ESI (negative): 307 (M+H).

Provenance & Evidence