HRID627134

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C=CCON([C@@H]1C=C(C)[C@@H](CO)N(C(=O)OC(C)(C)C)C1)S(=O)(=O)c1ccccc1[N+](=O)[O-]

HCID89852407

未命名化合物

结构：C=CCON([C@@H]1C=C(C(C)C)[C@@H](CO[Si](C)(C)C(C)(C)C)N(C(=O)OC(C)(C)C)C1)S(=O)(=O)c1ccccc1[N+](=O)[O-]

HCID89852426

未命名化合物

2 次

PRODUCTS

生成物

结构：C=CCON([C@@H]1C=C(C(C)C)[C@@H](CO)N(C(=O)OC(C)(C)C)C1)S(=O)(=O)c1ccccc1[N+](=O)[O-]

HCID89852457

未命名化合物

收率 87.2%

PROCEDURE

实验过程

(2S,5R)-tert-butyl 5-(N-(allyloxy)-2-nitrophenylsulfonamido)-2-(hydroxymethyl)-3-isopropyl-5,6-dihydropyridine-1(2H)-carboxylate (660 mg, 87%) was prepared a similar manner as described in Intermediate 81 as a yellow oil, using (2S,5R)-tert-butyl 5-(N-(allyloxy)-2-nitrophenylsulfonamido)-2-((tert-butyldimethylsilyloxy)methyl)-3-isopropyl-5,6-dihydropyridine-1(2H)-carboxylate (Intermediate 91, 0.928 g, 1.48 mmol) as a starting material.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0f1e03691b564dcfa0111c3558001947
来源数据集: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09309245B2
来源说明: uspto-grants-2016_04

反应 SMILES

C(ON([C@H]1CN(C(OC(C)(C)C)=O)[C@H](CO)C(C)=C1)S(C1C=CC=CC=1[N+]([O-])=O)(=O)=O)C=C.[CH2:34]([O:37][N:38]([C@H:51]1[CH2:56][N:55]([C:57]([O:59][C:60]([CH3:63])([CH3:62])[CH3:61])=[O:58])[C@H:54]([CH2:64][O:65][Si](C(C)(C)C)(C)C)[C:53]([CH:73]([CH3:75])[CH3:74])=[CH:52]1)[S:39]([C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][C:43]=1[N+:48]([O-:50])=[O:49])(=[O:41])=[O:40])[CH:35]=[CH2:36]>>[CH2:34]([O:37][N:38]([C@H:51]1[CH2:56][N:55]([C:57]([O:59][C:60]([CH3:61])([CH3:62])[CH3:63])=[O:58])[C@H:54]([CH2:64][OH:65])[C:53]([CH:73]([CH3:75])[CH3:74])=[CH:52]1)[S:39]([C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][C:43]=1[N+:48]([O-:50])=[O:49])(=[O:41])=[O:40])[CH:35]=[CH2:36]