(2S,5R)-5-(N-(allyloxy)-2-nitrophenylsulfonamido)-3-methyl-1,2,5,6-tetrahydropyridine-2-carboxamide → (2S,5R)-5-(N-(allyloxy)-2-nitrophenylsulfonamido)-3-isopropyl-1,2,5,6-tetrahydropyridine-2-carboxamide

HRID 627137노트

반응식

HRID 627137 반응식
C(ON([C@H]1CN[C@H](C(N)=O)C(C)=C1)S(C1C=CC=CC=1[N+]([O-])=O)(=O)=O)C=C.[CH2:28]([O:31][N:32]([C@H:45]1[CH2:50][N:49](C(OC(C)(C)C)=O)[C@H:48]([C:58](=[O:60])[NH2:59])[C:47]([CH:61]([CH3:63])[CH3:62])=[CH:46]1)[S:33]([C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][C:37]=1[N+:42]([O-:44])=[O:43])(=[O:35])=[O:34])[CH:29]=[CH2:30]>>[CH2:28]([O:31][N:32]([C@H:45]1[CH2:50][NH:49][C@H:48]([C:58]([NH2:59])=[O:60])[C:47]([CH:61]([CH3:63])[CH3:62])=[CH:46]1)[S:33]([C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][C:37]=1[N+:42]([O-:44])=[O:43])(=[O:35])=[O:34])[CH:29]=[CH2:30]

참가 물질

3

반응물 2

HCID 89852088(2S,5R)-5-(N-(allyloxy)-2-nitrophenylsulfonamido)-3-methyl-1,2,5,6-tetrahydropyridine-2-carboxamideHCID 89852417(2S,5R)-tert-butyl 5-(N-(allyloxy)-2-nitrophenylsulfonamido)-2-carbamoyl-3-isopropyl-5,6-dihydropyridine-1(2H)-carboxylate2회

생성물 1

HCID 89852180(2S,5R)-5-(N-(allyloxy)-2-nitrophenylsulfonamido)-3-isopropyl-1,2,5,6-tetrahydropyridine-2-carboxamide수율 86%

실험 절차

(2S,5R)-5-(N-(allyloxy)-2-nitrophenylsulfonamido)-3-isopropyl-1,2,5,6-tetrahydropyridine-2-carboxamide (160 mg, 86%) was prepared a similar manner as described in Intermediate 84 as a beige solid, using (2S,5R)-tert-butyl 5-(N-(allyloxy)-2-nitrophenylsulfonamido)-2-carbamoyl-3-isopropyl-5,6-dihydropyridine-1(2H)-carboxylate (Intermediate 94, 260 mg, 0.5 mmol) as a starting material.

출처 및 근거

ORD 기록
ord-18e198e2ced74c9391e3e42c7f980b62
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09309245B2

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