Tetrabutylammonium Fluoride → HCID 117940148, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of Intermediate 122 (1.7 g, 4.61 mmol) in THF (40 mL), TBAF (6.92 mL, 6.92 mmol) was added at 0° C. The reaction mixture was stirred at 0° C. for 1 hr. LCMS indicated the disappearance of starting material and formation of the desired product. The mixture was concentrated and purified by silica gel column (40 g, 50-100% Hex/EA) to give the title compound (1.050 g, 90%) as a white solid.

Provenance & Evidence