HCID 89852207, compound → HCID 89852208, compound

HRID 627188Notes

Reaction equation

HRID 627188 reaction equation
[Na].[S:2]([OH:20])([O:5][N:6]1[C:12](=[O:13])[N:11]2[CH2:14][C@H:7]1[CH:8]=[C:9]([CH2:18][OH:19])[C@H:10]2[C:15](=[O:17])[NH2:16])(=[O:4])=[O:3]>O>[S:2]([OH:20])([O:5][N:6]1[C:12](=[O:13])[N:11]2[CH2:14][C@H:7]1[CH:8]=[C:9]([CH2:18][OH:19])[C@H:10]2[C:15](=[O:17])[NH2:16])(=[O:4])=[O:3]

Participants

3

Reactant 1

HCID 89852207HCID 89852207, compound

Product 1

HCID 89852208HCID 89852208, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent3×

Procedure

Dowex 50WX8, 100-200 mesh (0.48 g, 6.43 μmol) resin in 2 mL water was loaded into a cartridge and let water run off. Trimethylammonium (2S,5R)-3-(((tert-butyldimethylsilyl)oxy)methyl)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl sulfate sodium salt (Intermediate 166, 3 mg, 6.43 μmol) in water was passed through the resin 2 times (pH is ˜3). The solution was carried forward to the final ion exchange column, see Example 18.

Sources & evidence

ORD record
ord-fa5f76302a0b439b9648c8b5fd558a52
Source dataset
uspto-grants-2016_04
Patent number
US09309245B2

Reaction notes

Loading…