HCID 89851371, compound → (2S,5R)-6-(allyloxy)-3-cyclopropyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-ene-2-carboxamide

HRID 627256Notes

Reaction equation

HRID 627256 reaction equation
[CH2:1]([O:4][NH:5][CH:6]1[CH2:11][NH:10][C@@H:9]([C:12]([NH2:14])=[O:13])[C:8]([CH:15]2[CH2:17][CH2:16]2)=[CH:7]1)[CH:2]=[CH2:3].[CH2:18]([O:21]N1C(=O)N2C[C@H]1C(C)=C[C@H]2C(N)=O)C=C>>[CH2:1]([O:4][N:5]1[C:18](=[O:21])[N:10]2[CH2:11][C@H:6]1[CH:7]=[C:8]([CH:15]1[CH2:16][CH2:17]1)[C@H:9]2[C:12]([NH2:14])=[O:13])[CH:2]=[CH2:3]

Participants

3

Reactant 2

HCID 89851371HCID 89851371, compoundHCID 89852304(R)-5-(allyloxyamino)-3-cyclopropyl-1,2,5,6-tetrahydropyridine-2-carboxamide2×

Product 1

HCID 89854618(2S,5R)-6-(allyloxy)-3-cyclopropyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-ene-2-carboxamide

Procedure

The title compound was prepared from (R)-5-(allyloxyamino)-3-cyclopropyl-1,2,5,6-tetrahydropyridine-2-carboxamide (Intermediate 244, 0.316 g, 1.33 mmol) following the procedure described for Intermediate 16. The desired product was obtained as a colorless oil (0.261 g, 74%).

Sources & evidence

ORD record
ord-d20fb0c1e22948f09541b1f90129d423
Source dataset
uspto-grants-2016_04
Patent number
US09309245B2

Reaction notes

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