HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S,5R)-6-(allyloxy)-2-((tert-butyldimethylsilyloxy)methyl)-4-methyl-1,6-diazabicyclo[3.2.1]oct-3-en-7-one → (2S,5R)-6-(allyloxy)-2-(methoxymethyl)-N-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-ene-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S,5R)-6-(allyloxy)-2-((tert-butyldimethylsilyloxy)methyl)-4-methyl-1,6-diazabicyclo[3.2.1]oct-3-en-7-one | HCID 89852160 | — |
| Reactant | (3R,6S)-3-(allyloxyamino)-6-(methoxymethyl)-N-methyl-1,2,3,6-tetrahydropyridine-4-carboxamide | HCID 89852327 | — |
| Product | (2S,5R)-6-(allyloxy)-2-(methoxymethyl)-N-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-ene-4-carboxamide | HCID 89852410 | 68% |
Reaction Steps
The title compound (0.28 g, 68%) was prepared according to the procedure described for Intermediate 13, starting from (3R,6S)-3-(allyloxyamino)-6-(methoxymethyl)-N-methyl-1,2,3,6-tetrahydropyridine-4-carboxamide (Intermediate 258, 0.52 g)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09309245B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-117a60bb1a1940a2a23bf8f07a767591 |
| Source note | uspto-grants-2016_04 |